Medical Study Summaries & Abstracts

Respiratory

• McElhaney JE, Gravenstein S, Cole SK, et al. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 2004 Jan;52(1) : 13-9.

Circulatory

• Shao ZH, Xie JT, Vanden Hoek, et al. Antioxidant effects of North American ginseng berry in cardiomyocytes exposed to acute oxidant stress. Biochem Acta 2004 Feb;1670(3):165-71
• Stavro PM, Woo M, Heim TF, Leiter LA, Vuksan V. North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension. Hypertension 2005; 46:1-6

Reproductive

• Murphy LL, Cadena RS, Chavez D, Ferraro JS. Effect of North American ginseng on male copulatory behavior in the rat. Physiol Behav 1998 June;64(4): 445-50
• Murphy LL, Lee TJ. Ginseng, sex behavior, and nitric oxide, Ann N Y Acad Sci 2002 May;969:372-7
• Duda RB, kang SS, Archer SY, Meng S, Hodin RA. North American ginseng transcriptionally activates p21 mRNA in breast cancer cell lines. J Korean Med. Sci 2001 Dec:16 Suppl: S54-60

Endocrine

• Vuksan V, Stavro MP, Sievenpiper JL, et al. American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation. J Am Coll Nutr 2000;19(6): 738-44.
• Vuksan V, Sievenpiper JL, Koo Vy, Francis T, Beljan Zdravkovic U, Xu Z, Vidgen E. American ginseng (Panax quinquefolius L) reduces post prandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch intern Med 2000. Arp;160(7): 1009-13

Immune System

• McElhaney JE, Gravenstein S, Cole SK, et al. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 2004 Jan;52(1) : 13-9.

Nervous System

• Sloley BD, Pang PK, Huang BH et al. North American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry. Neurosci 1999;24(5):442-52.
• Rudakawich M, Ba F, Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1) Planta Med 2001;67(6):533-7
• Lyon MR, Cline JC, Totosy de Zepetnak J, Shan JJ, Pang P, Benishin C. Effect of the herbal extract combination Panax Quinquefolium and ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci 2001;26(3);221-8

Digestive

• Mehendale S, Aung H, Wang A, Yin JJ, Wang CZ, Zie JT, Yuan CS, North American ginseng berry extract and ginsenoside. Cancer chemother pharmacol. 2005; 56 (1) 63-9
• Wang M, Guilbert LJ, Ling L, et al. Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). J. Pharm Pharmacol 2001; 53 (11) : 1515-23
• Assinewe VA, Amason JT, Aubry A, Mullin J, Lemaire I. Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate. TNFalpha production by alveolar macrophages. Phytomedicine 2002;9(5): 398-404
• Wang M, Guilbert LJ, Ling L, et al. A proprietary extract from North American ginseng (Panax quinquefolium). Enhances IL-2 and IFN-gamma productions in murine spleen cells induced by on-A. Int. Immunopharmacol 2004;4 (2):311-5.
• Wang HX, Ng TB. Quinquenginsin, a novel protein with anti-human immunodeficiency virus, antifungal, ribonuclease and cell-free translation-inhibitory activities from North American ginseng roots. Biochem Biophys Res Commun 2000;269(1):203-8